Elderly Patients with Metabolic Syndrome more likely to Develop CKD

Although the development of chronic kidney disease (CKD) has been found to be related to the presence of metabolic syndrome in middle age, there was no such study in the elderly people which could establish a similar link. However, according to a latest study, published in the journal Clinical Endocrinology and Metabolism, elderly patients, suffering from high insulin resistance, have been found to be more predisposed to developing a rapid loss of renal function whereas elderly patients suffering from metabolic syndrome have a higher probability of developing CKD.

The study was carried out by researchers from the National Taiwan University Hospital in Taipei. The lead researcher, Dr. Hui-Teng Cheng, from the Department of Internal Medicine, along with his colleagues, studied the incidence of development of CKD and a decline in renal function in 1456 elderly patients, all of whom were above 65 years of age. 39 percent of the participants suffered from metabolic syndrome. The participants were followed for an average of 3.15 years. The insulin resistance in 652 non-diabetic participants was measured using the homeostasis model. The annual decline of the estimated glomerular filtration rate was measured, as was the incidence and prevalence of CKD.

It was seen that individuals with high insulin resistance and high blood sugar levels are more likely to suffer from a rapid decline of renal function. Similarly, the presence of metabolic syndrome in the elderly patients was a good indicator of both the prevalence and incidence of CKD. The presence of even a single component of the metabolic syndrome increased the risk of CKD. The risk increased in proportion with the components of metabolic syndrome. A glomerular filtration rate of more than 3 mL/minute/1.73m2 was considered as a significant decline in the kidney function in the study. It was seen that participants with fasting blood glucose of more than 110 mg/dL had a higher chance of developing a significant decline in renal function. The odds of prevalent CKD rose by 1.312 and the odds of proteinuria rose by 1.278 for every unit increase of insulin resistance.

Sunday, March 18, 2012
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