Persistent Microscopic Hematuria in Young Adults can lead to an Increased Risk of Developing ESRD

The results of a retrospective, population based study conducted in Israel indicate that a persistent microscopic hematuria in adolescents and young adults can lead to an increased risk of developing end stage renal disease (ESRD). The study, which has been published in the August 17 issue of the Journal of the American Medical Association, examined 1,203,626 persons between the ages of 16 and 25 years who had applied for military service, for fitness, between 1975 and 1997. Around 60% of these young adults were males. The participants were followed up for duration of 21.88 ± 6.74 years.

The researchers found that among the participants, 3690 (0.3%) had persistent asymptomatic isolated microscopic hematuria. Of these, 26 individuals (0.70%) with hematuria and 539 (0.045%) without persistent asymptomatic isolated microscopic hematuria went on to have treated ESRD. They found that the risk for ESRD developing associated with persistent asymptomatic isolated microscopic hematuria was similar in all people with comparable age, sex, paternal country of origin, year of enrollment, body mass index, and baseline blood pressure. The ESRD developed in these patients with hematuria was caused by primary glomerular disease. According to Asaf Vivante, MD, from the Edmond and Lily Safra Children's Hospital in Tel Hashomer, Israel, and the lead author of the study, presence of persistent asymptomatic isolated microscopic hematuria in persons aged 16 through 25 years was associated with significantly increased risk of treated ESRD for a period of 22 years, although the incidence and absolute risk remain quite low.

In light of the results of the above mentioned study, assessment of microscopic hematuria in young adults may be added to assessment of albuminuria in adults middle-aged and older as a tool to detect chronic kidney disease (CKD) early. This will help in minimizing the high rates of morbidity associated with CKD.

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Date: 
Saturday, August 27, 2011
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