Nicotinamide Riboside present in Milk may protect against Obesity
Milk has always been known as a rich source of calcium and has been prescribed for its growth boosting effect. However, a new research, published in the journal Cell Metabolism, has found another advantage of drinking milk. The researchers from the École Polytechnique Fédérale de Lausanne have found that an ingredient of milk, called as nicotinamide riboside may be acting as a vitamin effective against obesity.
A gene, known as the SIRT1 gene is known for boosting metabolism and longevity. The researchers, led by Johan Auwerx, were finding ingredients which can further supplement the action of SIRT1. Until now, scientists only knew about resveratrol, an ingredient of red wine, to possess this kind of property. SIRT1 gene requires a cofactor NAD+ for its action. Auwerx’s team tried to find out ways to boost NAD+. They found that an ingredient commonly found in milk, called as nicotinamide riboside, can potentiate the action of NAD+. It increases the levels of NAD+ in the mammalian cells and its supplementation enhances the activities of SIRT1 and SIRT3 genes. Nicotinamide riboside protects the body against the dangerous metabolic side effects of consuming a diet rich in fat. So, mice receiving this ingredient in high doses along with meals rich in fat tend to burn more fat and do not become obese. Nicotinamide riboside is also believed to increase the functioning capacity of the mitochondria present in the cells and aids during endurance performance. Therefore, mice taking it become better runners.
Nicotinamide riboside is a naturally occurring precursor of NAD+ which can increase the replicative life span in yeast. As it increases the oxidative metabolism and provides protection against obesity resulting from a high fat diet, the researchers have opined that it can be used as a nutritional supplement to fight against age related and metabolic disorders arising due to defect in the functioning of the mitochondria.