Antidepressant drugs and post-operative surgical pain

antidepressants in post operative pain
    Post-operative pain can be sometimes difficult to treat with the usual pain killers.  Unresolved post-operative pain has been associated with poor overall outcomes including prolonged hospitalization. Hence sometimes drugs like antidepressants have been tried to counter recalcitrant post-operative pain, though scientifically not well validated.  Previous studies done to answer this specific issue have shown inconclusive and contradictory results.    Dr Ian Gilron, professor and...

Effective Dose of Propofol is lower in Obese Children

According to a recent study presented at the 2011 annual meeting of the American Society of Anesthesiologists, the effective dose of propofol in 95% of the patients (ED95) is significantly lower in obese children. This is because propofol is a lipophilic drug. More than 75 percent of the excess weight of obese children is comprised of fat tissue whereas only 25% is the actual or lean weight. The fat tissue interferes with the distribution of lipophilic drugs, like propofol. Any excess drug...

More likelihood of Acute Kidney Injury during Hip Stabilization Surgery under GA

According to a study presented at the 2011 annual spring meeting of the American Society of Regional Anesthesia and Pain Medicine, the chances of developing acute kidney injury (AKI) in patients undergoing hip stabilization surgery are much higher when the surgery is performed under general anesthesia compared to when it is performed under regional anesthesia. The research was conducted by the researchers from University of Florida College of Medicine, Gainesville. The researchers made this...

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